Simply put, no other goalkeeper comes close to him in the league. Probably the best in the world. Barring any last minute injury, David de Gea should start in goal.
With the first choice defensive setup injured, a makeshift defence is expected. Matteo Darmian should start at right back after impressing against Swansea last time. Phil Jones is back from a long term injury and should slot in alongside Daley Blind. The Dutch international has been far from impressive this season, but should get the nod. Marcos Rojo would fill in at left back, in place of the doubtful Luke Shaw.
A trident of Herrera, Pogba and Carrick feels most likely to start the game today. The trio offers balance, guile and power in equal measure. Herrera has been quite impressive in recent weeks, while Pogba is beginning to show flashes of his quality, as he has Michael Garrick beside him who orchestrates things from deep. Marcus Rashford and Anthony Martial should occupy the flanks. Their pace and attacking instincts will be crucial, especially if Jose plans to play on the counter.
11 career goals against Arsenal tells the story of how Wayne Rooney loves playing against them. He should start despite the recent criticism about him and the drinking incident while on England duty last week.
Expected lineup: De Gea, Darmian, Jones, Blind, Rojo, Herrera, Carrick, Pogba, Rashford, Martial, Rooney.